In vitro evaluation of the pharmaceutical properties of a toothpaste which contains an association of Fluorinol® and of enoxolone. - ROS - 2012 - Tome 41 - N°3

INTRODUCTION: The main aim of this study was to evaluate the behaviour of the two active principles, enoxolone and
nicomethanol fluorhydrate, individually and when associated in the same toothpaste.
MATERIAL AND METHOD: Two different experimental models have been used. The anti-inflammatory effect of toothpastes
has been evaluated thanks to a first model of gingiva maintained alive ex vivo, and on which have been applied the experimental conditions of gingival inflammation, by the addition of substance P and LPS. The measure of free fluorine and of fluorination have been measured in a second experimental model. The entirety of this study is blind and placebo controlled.
RESULTS: The toothpastes which contain only enoxolone or with Fluorinol® brought about an important reduction of both the cellular inflammatory signs (reduction of the oedema and dilation of the capillaries) and the molecular signs (reduction of the liberation of interleukin-8). The liberation of fluorine and the fluorination of the ceramic discs is identical with or without enoxolone.
DISCUSSION: In this study, there is no antagonism between the two active principles when they are associated in a toothpaste.